The tutorial provides a brief overview of the key historical events that have shaped the modern U.S. nuclear weapon system safety design philosophy, followed by a brief overview of the nuclear weapon safety process after which there is a focus on describing the nuclear safety design principles of incompatibility, isolation, and inoperability, and the way they are implemented. Key considerations include subtle aspects of the incompatibility and isolation design principles and techniques for developing and integrating multiple safety layers (a.k.a., subsystems) of safety features each having independent failure causes such that the resulting system safety can be asserted to meet stringent safety requirements in a predictable manner in all relevant environments.